Research

Projects

  • Proton transfer and hydrogen bonds: contribution in biomolecular assembly and function.1–4
  • Spectroscopy of small molecular interactions with biological targets and development of molecular probes.5–11
  • Cycloaddition and click chemistry: synthesis of biologically relevant small molecules.12–14
  • Study of hazardous materials: health and environment.15
  • Development of nanobiomaterials: drug delivery and tissue engineering.16,17
  • Developing resources for computational drug discovery.18,19
  • Drug leads from natural products.20–22
  • Study of the intrinsically disordered proteins, aggregates and amyloidosis such as Alzheimer’s and Parkinson’s diseases.23–26
  • Inflammation, extracellular matrix remodeling and metastasis: development of matrixmetalloprotease modulators.21,27
  • Cancer: development of chemotherapeutic drugs and small molecule modulators of oncogenic proteins.7,28,29
  • Infectious diseases: drug development for malaria, Leishmaniasis and HIV.20,30

Publications (Follow my publications on Google Scholar)

  1. Pal U, Sen S, Maiti NC. Cα–H carries information of a hydrogen bond involving the geminal hydroxyl group: a case study with a hydrogen-bonded complex of 1,1,1,3,3,3-hexafluoro-2-propanol and tertiary amines. J Phys Chem A 2014;118:1024–30. doi:10.1021/jp411488a.
  2. Sen S, Pal U, Maiti NC. pKa determination of D-ribose by Raman spectroscopy. J Phys Chem B 2014;118:909–14. doi:10.1021/jp4092392.
  3. Naiya G, Raha P, Mondal MK, Pal U, Saha R, Chaudhuri S, et al. Conformational selection underpins recognition of multiple DNA sequences by proteins and consequent functional actions. Phys Chem Chem Phys 2016;18:21618–28. doi:10.1039/C6CP03278H.
  4. Das S, Pal U, Maiti NC. Metal ions provide structural stability and compactness to tetrameric purothionin. RSC Adv 2016;6:90690–700. doi:10.1039/C6RA16576A.
  5. Pal U, Pramanik SK, Bhattacharya B, Banerji B, Maiti NC. Binding interaction of a novel fluorophore with serum albumins: steady state fluorescence perturbation and molecular modeling analysis. SpringerPlus 2015;4:548. doi:10.1186/s40064-015-1333-8.
  6. Pal U, Pramanik SK, Bhattacharya B, Banerji B, Maiti NC. Binding interaction of a gamma-aminobutyric acid derivative with serum albumin: an insight by fluorescence and molecular modeling analysis. SpringerPlus 2016;5:1121. doi:10.1186/s40064-016-2752-x.
  7. Banerji B, Pramanik SK, Pal U, Maiti NC. Potent anticancer activity of cystine-based dipeptides and their interaction with serum albumins. Chem Cent J 2013;7:91. doi:10.1186/1752-153X-7-91.
  8. Mitra P, Pal U, Maiti NC, Ghosh A, Bhunia A, Basu S. Identification of modes of interactions between 9-aminoacridine hydrochloride hydrate and serum proteins by low and high resolution spectroscopy and molecular modeling. RSC Adv 2016;6:53454–68. doi:10.1039/C6RA04140J.
  9. Banerjee M, Pal U, Subudhhi A, Chakrabarti A, Basu S. Interaction of Merocyanine 540 with serum albumins: photophysical and binding studies. J Photochem Photobiol B 2012;108:23–33. doi:10.1016/j.jphotobiol.2011.12.005.
  10. Ray A, Seth BK, Pal U, Basu S. Nickel(II)-Schiff base complex recognizing domain II of bovine and human serum albumin: spectroscopic and docking studies. Spectrochim Acta A Mol Biomol Spectrosc 2012;92:164–74. doi:10.1016/j.saa.2012.02.060.
  11. Banerji B, Chatterjee M, Pal U, Maiti NC. Molecular details of acetate binding to a new diamine receptor by NMR and FT-IR analyses. J Phys Chem A 2016;120:2330–41. doi:10.1021/acs.jpca.6b01078.
  12. Banerji B, Chandrasekhar K, Killi SK, Pramanik SK, Pal U, Sen S, et al. Silver-catalysed azide–alkyne cycloaddition (AgAAC): assessing the mechanism by density functional theory calculations. R Soc Open Sci 2016;3:160090. doi:10.1098/rsos.160090.
  13. Bhattacharya D, Ghorai A, Pal U, Maiti NC, Chattopadhyay P. Stereoselective domino azidation and [3 + 2] cycloaddition: a facile route to chiral heterocyclic scaffolds from carbohydrate derived synthons. RSC Adv 2013;4:4155–62. doi:10.1039/C3RA45363D.
  14. Bhattacharya D, Ghorai A, Pal U, Chandra Maiti N, Chattopadhyay P. ChemInform abstract: stereoselective domino azidation and [3 + 2] cycloaddition: a facile route to chiral heterocyclic scaffolds from carbohydrate derived synthons. ChemInform 2014;45:38–188. doi:10.1002/chin.201438188.
  15. Banerji B, Pramanik SK, Pal U, Maiti NC. Binding of hemoglobin to ultrafine carbon nanoparticles: a spectroscopic insight into a major health hazard. RSC Adv 2014;4:22536–41. doi:10.1039/C4RA02569E.
  16. Banerji B, Pramanik SK, Pal U, Maiti NC. Dipeptide derived from benzylcystine forms unbranched nanotubes in aqueous solution. J Nanostructure Chem 2013;3:12. doi:10.1186/2193-8865-3-12.
  17. Maity M, Pramanik SK, Pal U, Banerji B, Maiti NC. Copper(I) oxide nanoparticle and tryptophan as its biological conjugate: a modulation of cytotoxic effects. J Nanoparticle Res 2014;16:2179. doi:10.1007/s11051-013-2179-z.
  18. Pal U. Interaction of proteins with small molecules and peptides. Doctoral dissertation. Jadavpur University, 2016.
  19. Pal U, Maiti NC. Allostery and druggability prediction by molecular docking. J Proteins Proteomics 2015;3:133.
  20. Alam A, Haldar S, Thulasiram HV, Kumar R, Goyal M, Iqbal MS, et al. Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor. J Biol Chem 2012;287:24844–61. doi:10.1074/jbc.M112.341321.
  21. Rudra DS, Pal U, Maiti NC, Reiter RJ, Swarnakar S. Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site. J Pineal Res 2013;54:398–405. doi:10.1111/jpi.12034.
  22. Talapatra SN, Talukdar P, Pal U, Maiti NC, Swarnakar S. Interaction of T-state haemoglobin and phytochemicals of Hygrophila spinosa T. Anders: an approach by molecular docking. World J Pharm Res 2016;5:1354–69.
  23. Pal U, Maity M, Khot N, Das S, Das S, Dolui S, et al. Statistical insight into the binding regions in disordered human proteome. J Proteins Proteomics 2016;7:47.
  24. Das S, Pal U, Das S, Maiti NC. Chaperone action of cyclophilin on lysozyme and its aggregate. J Proteins Proteomics 2013;4:129.
  25. Das S, Pal U, Das S, Bagga K, Roy A, Mrigwani A, et al. Sequence complexity of amyloidogenic regions in intrinsically disordered human proteins. PLoS ONE 2014;9:e89781. doi:10.1371/journal.pone.0089781.
  26. Das S, Das S, Roy A, Pal U, Maiti NC. Orientation of tyrosine side chain in neurotoxic Aβ differs in two different secondary structures of the peptide. R Soc Open Sci 2016;3:160112. doi:10.1098/rsos.160112.
  27. Alam A, Pal C, Goyal M, Kundu MK, Kumar R, Iqbal MS, et al. Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent. Bioorg Med Chem 2011;19:7365–73. doi:10.1016/j.bmc.2011.10.056.
  28. Bhowmik A, Das N, Pal U, Mandal M, Bhattacharya S, Sarkar M, et al. 2,2’-diphenyl-3,3’-diindolylmethane: a potent compound induces apoptosis in breast cancer cells by inhibiting EGFR pathway. PloS One 2013;8:e59798. doi:10.1371/journal.pone.0059798.
  29. Banerji B, Pramanik SK, Pal U, Maiti NC. Conformation and cytotoxicity of a tetrapeptide constellated with alternative D- and L-proline. RSC Adv 2012;2:6744–7. doi:10.1039/C2RA20616A.
  30. Saha S, Acharya C, Pal U, Chowdhury SR, Sarkar K, Maiti NC, et al. A novel spirooxindole derivative inhibits the growth of Leishmania donovani parasite both in vitro and in vivo by targeting type IB topoisomerase. Antimicrob Agents Chemother 2016:AAC.00352-16. doi:10.1128/AAC.00352-16.
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